ANTI-ANGIOGENIC VEGF-AX ISOFORM
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United States of America Patent
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Jan 27, 2014
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Jan 27, 2013
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Abstract
A VEGF-Ax polypeptide, as well as a smaller Ax poly-peptide, both having anti-angiogenic activity that can be used for treating or preventing angiogenesis are described. An antibody specific to the Ax region of a VEGF-Ax polypeptide, as well as an antibody specific to the C-terminus region of a VEGF-A polypeptide that is not capable of binding to VEGF-Ax, and methods of using these antibodies, are also described.
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