Methods of determining levels of cleaved and/or intact kininogen

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11156612
APP PUB NO 20150362493A1
SERIAL NO

14761690

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Abstract

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The present disclosure provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITEDOSAKA-SHI OSAKA 541-0045

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adelman, Burt Concord, US 20 90
Chyung, Yung Lexington, US 13 49
Conley, Gregory P Arlington, US 9 37
Faucette, Ryan Melrose, US 18 74
Kenniston, Jon A Hingham, US 13 51
Nixon, Andrew Hanover, US 38 354
Sexton, Daniel J Melrose, US 56 508
TenHoor, Christopher Hopkinton, US 22 150

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