METHODS FOR INDUCTION OF CELL FATES FROM PLURIPOTENT CELLS
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United States of America Patent
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Issued Date -
Dec 24, 2015
app pub date -
Feb 14, 2014
filing date -
Feb 14, 2013
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Abstract
A method of inducing pancreatic fates from human multipotent or pluripotent cells includes obtaining a cell population comprising human multipotent or pluripotent cells and providing the cell population with at least three of (i) an CXCR4 agonist, (ii) an EGFR agonist, (iii) an FGFR agonist, (iv) an Activin receptor agonist or an agent that stimulates SMAD3, (v) an IL11R agonist or IL6R agonist, (vi) a notch agonist, (vii) an RXR agonist or RAR agonist, or (viii) a BMP inhibitor for a time effective to allow the differentiation of pancreatic precursor cells from the human multipotent or pluripotent cells.
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