HUMAN ANTIBODIES TO HUMAN DELTA LIKE LIGAND 4
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United States of America Patent
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Issued Date -
Dec 31, 2015
app pub date -
Jun 3, 2015
filing date -
Dec 14, 2006
priority date (Note) -
Abandoned
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Abstract
The present invention provides methods of treating, ameliorating, or inhibiting tumor growth, cancer, or pathological angiogenesis by administering to a subject in need thereof a human antibody or fragment thereof that specifically binds to human delta-like ligand 4 (hDll4) and blocks hDll4 binding to a Notch receptor. The anti-hDll4 antibody or fragment thereof of the present invention have a high affinity with the KD of 500 pM or less, as measured by surface plasmon resonance.
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