Methods of inhibiting IGF-1R activation or downtream signalling thereof to reduce radiation-induced cellular senescence

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United States of America Patent

PATENT NO 10799473
APP PUB NO 20160000744A1
SERIAL NO

14771171

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Abstract

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Accelerated senescence has been shown to occur as a primary response to cellular stresses including DNA damaging agents (e.g., ionizing radiation) and is widely believed to be caused by continuous proliferative signaling in the presence of cell cycle arrest. The present disclosure provides a method of reducing cellular senescence in non-cancerous cells following exposure to ionizing radiation. The method comprises administering to a subject before, after, or concurrently with exposure to ionizing radiation an effective amount of a compound that inhibits activation of an insulin-like growth factor receptor (IGF-1R) or a compound that inhibits a protein involved in an IGF-1R induced signaling cascade. Also provided is a composition for use in reducing cellular senescence in non-cancerous cells following exposure to ionizing radiation, the composition comprising a compound that inhibits activation of an insulin-like growth factor receptor (IGF-1R) or a compound that inhibits a protein involved in an IGF-1R induced signaling cascade.

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Patent Owner(s)

Patent OwnerAddress
THE HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INC6720A ROCKLEDGE DRIVE SUITE 100 BETHESDA MD 20817

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Day, Regina M Rockville, US 2 8
Panganiban, Ronald-Allan M Bethesda, US 1 8

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