Anti-ASIC1 Antibodies and Uses Thereof
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United States of America Patent
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Jan 7, 2016
app pub date -
Sep 9, 2015
filing date -
Jan 31, 2012
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Abstract
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind to cells expressing acid-sensing ion channel-1 (ASIC1). According to certain embodiments of the invention, the antibodies inhibit acid-induced, ASIC1-mediated ion currents in cells expressing human ASIC1. The antibodies of the invention are useful for the treatment of pain, including pain associated with surgical intervention and various diseases and disorders.
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