FORMULATIONS AND METHODS FOR INCREASED RECOMBINANT PROTEIN PRODUCTION

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United States of America Patent

SERIAL NO

14770064

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Formulations and methods to increase the production of recombinant proteins, and other aspects, are disclosed. The formulations and methods relate to increasing mannose or calcium concentration, or both, in a cell culture medium formulation for culturing cells that express recombinant proteins. In some embodiments, a mammalian cell culture medium formulation is provided that has at least one of mannose at about 3.5 g/L or more and calcium in a range from about 1.5 mM to about 9.5 mM. Numerous other aspects and/or embodiments are provided.

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Patent Owner(s)

Patent OwnerAddress
BAYER HEALTHCARE LLC555 WHITE PLAINS ROAD TARRYTOWN NY USA 10591

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Matanguihan, Ricaredo Walnut Creek, US 3 28
Moehrle, Volker Köln, DE 3 3
Shimoni, Yuval Berkeley, US 5 3
Srinivasan, Venkatesh Campbell, US 52 484

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