Quantitative assessment for cap efficiency of messenger RNA

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United States of America Patent

PATENT NO 10626439
APP PUB NO 20160002705A1
SERIAL NO

14775844

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Abstract

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The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly mRNA synthesized in vitro. In some embodiments, methods according to the present invention comprise providing an mRNA sample containing capped and uncapped mRNA, providing a cap specific binding substance under conditions that permit the formation of a complex between the cap specific binding substance and the capped mRNA, and quantitatively determining the amount of the complex as compared to a control, thereby quantifying mRNA capping efficiency.

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Patent Owner(s)

Patent OwnerAddress
TRANSLATE BIO INC200 WEST STREET WALTHAM MA 02451

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeRosa, Frank Cambridge, US 261 2650
Dias, Anusha Cambridge, US 61 360
Heartlein, Michael Boxborough, US 223 2893

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