Method of Labeling Flumazenil with F-18 and Separating and Purifying F-18-Flumazenil
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United States of America Patent
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Issued Date -
Jan 21, 2016
app pub date -
Jul 17, 2014
filing date -
Jul 17, 2014
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Abandoned
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Abstract
Flumazenil (FMZ) is labeled with fluorine(F)-18 to obtain F-18-flumazenil. F-18-flumazenil can be strongly combined with type-A acceptor of gamma-aminobutyric acid (GABAA) in brain for tracing. The time and temperature for labeling is saved and lowered. The toxic chemical, acetonitrile, used in separation and purification can be prevented. The present invention has a simplified procedure for evaluating mental disease medicines in a short time. Moreover, time for developing medicines for treating related diseases of the central nervous system can be reduced.
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