Process for the Production of Cyclosporin-A Using the Fungus Tolypocladium Sp. Strain NRRL No.: 18950
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United States of America Patent
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Jan 21, 2016
app pub date -
Mar 12, 2014
filing date -
Mar 12, 2013
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Provided herein is a process for the production of Cyclosporin-A (Cyc-A) including the steps of inoculating a nutrient medium with the fungus Tolypocladium sp., strain NRRL No. 18950 followed by cultivation under static conditions to obtain a fermented medium with the fungal biomass, and harvesting the biomass and subjecting the harvested biomass to extraction followed by purification to obtain pure Cyc-A. The nutrient medium includes glucose, glycerol, casein acid hydro lysate, malt extract, peptone, and L-valine.
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