IKAROS INHIBITION TO AUGMENT ADOPTIVE T CELL TRANSFER
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United States of America Patent
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Issued Date -
Jan 21, 2016
app pub date -
Mar 6, 2014
filing date -
Mar 6, 2013
priority date (Note) -
Abandoned
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Abstract
The present invention provides compositions and methods for inhibiting Ikaros in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of Ikaros in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.
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