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Abstract

The present disclosure is directed to methods of identifying neuroprotective PKC activators comprising analyzing candidate PKC activators to determine if they are non-tumorigenic, non-toxic, accessible to the brain, have α and ε specificity, result in minimal down regulation of the ε isozyme, are synapatogenic, and are anti-apoptotic. The methods disclosed herein may further comprise analyzing candidate PKC activators to determine whether they are neuroprotective against ASPD, protect against in vivo neurodegeneration, enhance learning and memory in normal animal models, induce downstream synaptogenic biochemical events, activate A-β degrading enzymes, inhibit GSK-3β, and/or activate alpha-secretase.

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First Claim