AGENT AND METHOD FOR MODIFYING THE 5' CAP OF RNA
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United States of America Patent
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Issued Date -
Feb 4, 2016
app pub date -
Dec 6, 2013
filing date -
Dec 10, 2012
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Abandoned
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Abstract
An agent and method for modifying the 5′ cap of RNA, for example for the purposes of isolation and analysis. According to one aspect the invention provides modified enzymes, namely modified trimethylguanosine synthases 2 from Giardia lamblia (GlaTGS2), the enzymatic activity of which is changed such that as compared to wild type enzymes the former can use AdoMet analogues better as cofactors.
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