2-HYDROXYGLUTARATE AS A BIOMARKER FOR CHRONIC HYPOXIA
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United States of America Patent
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Issued Date -
Feb 4, 2016
app pub date -
Nov 28, 2012
filing date -
Nov 18, 2011
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Abstract
The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic.
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Patent Owner(s)
Patent Owner | Address | |
---|---|---|
SLOAN KETTERING INST CANCER | USA NEW YORK |
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Thompson, Craig B | New York, US | 60 | 2531 |
Ward, Patrick S | New York, US | 5 | 6 |
Wise, David R | New York, US | 7 | 16 |
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