NOVEL MEDICAMENTS COMPRISING AN ANTIBODY COMPOSITION ENRICHED WITH PREDOMINANT CHARGE ISOFORM
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United States of America Patent
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Feb 18, 2016
app pub date -
Mar 14, 2014
filing date -
Mar 15, 2013
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Abstract
The present invention lies in the technical field of antibody therapies involving a mechanism of target-cell destruction by ADCC. It relates to purified antibody compositions, obtained by chromatographic fractionation of the various charge isoforms naturally present in an antibody composition and combining one or more chromatographic fractions corresponding to the predominant peak of the chromatogram, the resulting monoclonal antibody composition being enriched in said predominant peak, said peak representing at least 85% of the chromatogram of the composition obtained, for use as a medicament.
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