for the treatment of solid tumors in humans

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United States of America Patent

PATENT NO 10617723
APP PUB NO 20160051597A1
SERIAL NO

14781273

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Abstract

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The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1×103-1×107 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a human, methods for ablating a solid tumor present in a human, a method for microscopically precise excision of tumor cells in a human, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a human, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a human are also provided.

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Patent Owner(s)

  • BIOMED VALLEY DISCOVERIES, INC.; THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kinzler, Kenneth W Bel Air, US 281 4765
Saha, Saurabh Wellesley Hills, US 49 162
Vogelstein, Bert Baltimore, US 323 6289
Zhou, Shibin Owings Mills, US 28 39

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