MODULATION OF ANGIOPOIETIN-LIKE 3 EXPRESSION

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United States of America Patent

APP PUB NO 20160060626A1
SERIAL NO

14821982

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Abstract

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Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.

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Patent Owner(s)

Patent OwnerAddress
IONIS PHARMACEUTICALS INC2855 GAZELLE COURT CARLSBAD CA 92010

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crooke, Rosanne M Carlsbad, US 100 2319
Dobie, Kenneth W Solana Beach, US 319 3223
Graham, Mark J San Clemente, US 123 2420
Lee, Richard Oceanside, US 139 1964

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