Methods for selectively suppressing non-target sequences

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United States of America Patent

PATENT NO 11408024
APP PUB NO 20160068889A1
SERIAL NO

14848887

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Abstract

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The invention generally relates to negative selection of nucleic acids. The invention provides methods and systems that remove unwanted segments of nucleic acid in a sample so that a target gene or region of interest may be analyzed without interference from the unwanted segments. A sample is obtained that includes single-stranded nucleic acid with one or more unwanted segments. Complementary nucleic acid is added to the single-stranded nucleic acid to create a double-stranded region that includes the unwanted segment. The double-stranded region is then digested, leaving single-stranded nucleic acid that includes the target gene or region of interest. This allows paralogs, pseudogenes, repetitive elements, and other segments of the genome that may be similar to the target gene or region of interest to be removed from the sample.

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Patent Owner(s)

Patent OwnerAddress
MOLECULAR LOOP CORPORATION300 TRADECENTER SUITE 5400 WOBURN MA 01801

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gole, Jeff Cambridge, US 4 56
Gore, Athurva Cambridge, US 14 183
Umbarger, Mark Brookline, US 39 632

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