METAL COMPLEXES AND THEIR FLUORINATION
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United States of America Patent
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Issued Date -
Mar 17, 2016
app pub date -
May 2, 2014
filing date -
May 3, 2013
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Abstract
A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilised to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
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