THERMOSENSITIVE MUTANTS OF INFLUENZA VIRUSES
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United States of America Patent
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Issued Date -
Mar 17, 2016
app pub date -
Apr 18, 2014
filing date -
Apr 18, 2013
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Abandoned
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Abstract
The invention relates to thermosensitive mutants of influenza viruses, containing at least one mutation localised in a flexible region of a protein of said virus, such as especially the region of the sub-unit PA of the viral polymerase corresponding to the region 197-225 of the sub-unit PA of influenza A. These viruses can be especially used for preparing attenuated living vaccines.
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