Amino lipids and methods for the delivery of nucleic acids
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United States of America Patent
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May 19, 2020
Grant Date -
Apr 7, 2016
app pub date -
Aug 28, 2015
filing date -
Oct 9, 2008
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Abstract
The present invention provides superior compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of specific target proteins at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
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