Small molecule RNase inhibitors and methods of use

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United States of America Patent

PATENT NO 9693999
APP PUB NO 20160115124A1
SERIAL NO

14933804

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Abstract

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Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

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Patent Owner(s)

  • TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA;UNIVERSITY OF ROCHESTER

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Childers, Wayne New Hope, US 7 9
Dunman, Paul M Pittsford, US 11 13
Olson, Patrick D St. Louis, US 4 5

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