Coprocessed silica coated polymer composition
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United States of America Patent
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Jan 8, 2019
Grant Date -
May 5, 2016
app pub date -
Mar 12, 2014
filing date -
Mar 12, 2013
priority date (Note) -
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status (Latency Note)
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Abstract
An excipient composition having good bulk density and improved flow characteristics is provided. The present invention particularly provides a coprocessed excipient composition and a method of producing the same. The coprocessed excipient comprises cellulose derived polymer and a deagglomerated coprocessing agent. The coprocessing agent is fumed silica, colloidal silica or silicon dioxide. The coprocessed excipient is prepared in a continuous process and has excellent compactability and improved flow property as measured by Johanson flow rate number increase from 1.1 to 5.0 fold, is characterized by a Brookfield cohesion factor of less than 0.2 kPa and a bulk density of at least 0.249 g/ml.
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