NGAL AND URINARY TRACT INFECTION
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United States of America Patent
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Issued Date -
May 19, 2016
app pub date -
Jul 8, 2015
filing date -
May 7, 2010
priority date (Note) -
Abandoned
status (Latency Note)
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Abstract
In some embodiments, the present invention is directed to compositions and methods for the treatment and prevention of urinary tract infections (UTIs) and urosepsis. In some embodiments, the methods of the invention comprise administering to a subject in need thereof a therapeutically effective amount of an agent that stimulates genito-urinary tract epithelial cells to produce NGAL, and/or an NGAL protein or a functional derivative thereof, and optionally also administering to the subject an additional agent useful for treating or preventing UTI or urosepsis. In other embodiments, the present invention also provides methods of screening for agents that stimulate urinary tract epithelial cells to produce NGAL.
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