DNA sequencing using multiple metal layer structure with different organic coatings forming different transient bondings to DNA

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United States of America Patent

PATENT NO 9513277
APP PUB NO 20160139105A1
SERIAL NO

15005174

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A nanodevice includes a reservoir filled with conductive fluid and a membrane separating the reservoir. A nanopore is formed through the membrane having electrode layers separated by insulating layers. A certain electrode layer has a first type of organic coating and a pair of electrode layers has a second type. The first type of organic coating forms a motion control transient bond to a molecule in the nanopore for motion control, and the second type forms first and second transient bonds to different bonding sites of a base of the molecule. When a voltage is applied to the pair of electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels via the first and second transient bonds formed to be measured as a current signature for distinguishing the base. The motion control transient bond is stronger than first and second transient bonds.

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Patent Owner(s)

  • INTERNATIONAL BUSINESS MACHINES CORPORATION

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Afzali-Ardakani, Ali Ossining, US 281 3233
Harrer, Stefan Hampton, AU 78 600
Luan, Binquan Pleasantville, US 51 354
Peng, Hongbo Chappaqua, US 52 698
Rossnagel, Stephen M Pleasantville, US 83 1801
Royyuru, Ajay K Congers, US 39 360
Stolovitzky, Gustavo A Riverdale, US 76 869
Waggoner, Philip S Fishkill, US 14 194

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