RAGE AS A C1Q RECEPTOR, METHODS AND APPLICATIONS
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United States of America Patent
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May 19, 2016
app pub date -
Feb 12, 2014
filing date -
Feb 12, 2014
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Abstract
A method of identifying a compound capable of reducing or increasing the amount of the receptor for RAGE-C1q Binding comprising a) providing an amount of the compound to be tested; b) contacting the amount of the compound with C1q and RAGE; c) measuring the amount of RAGE-C1q binding in step b); d) comparing the amount of RAGE-C1q binding measured in step c) with the amount of RAGE-C1q binding measured under corresponding conditions in the absence of the compound; and e) identifying the compound as capable of reducing or increasing the amount of RAGE-C1q binding. The present invention also provides a method of treating a subject suffering from a RAGE-related disorder comprising administering to the subject a therapeutically effective amount of a compound that is a modulator of the amount of RAGE-C1q binding so as to thereby treat the subject.
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