Allosteric inhibitors of proteasome and methods of use thereof

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United States of America Patent

PATENT NO 10167259
APP PUB NO 20160152567A1
SERIAL NO

14896984

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Abstract

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The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions thereof. Specifically piperidine-2-carboxylic acid derivatives containing 1-oxo-aroyl group and a lipophilic ester side chain are disclosed as allosteric inhibitors of proteasome 2S activity, and as therapeutic agents for the treatment of proteasome-associated disorders in a subject.

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Patent Owner(s)

  • THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gaczynska, Maria E San Antonio, US 4 2
Osmulski, Pawel A San Antonio, US 6 2

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