Truncated Constructs of RIPK3 and Related Uses
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United States of America Patent
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Jun 9, 2016
app pub date -
Apr 30, 2014
filing date -
May 1, 2013
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Abstract
The invention provides methods and compositions for inducing necroptosis in target cells, including for example cancer cells. This invention provides compositions and methods for the controlled expression and formation of full length RDPK3 homodimers, truncated RTPK3 oligomers and/or full length RIPK3/RIPK1 heterodimers in target cells both in vitro and in vivo therapeutic and research applications.
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