Tyrosine kinome

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United States of America Patent

PATENT NO 9926606
SERIAL NO

14960681

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Abstract

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Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in NTRK3, FES, GUCY2F and a previously uncharacterized tyrosine kinase gene called MCCK/MLK4. Most alterations were in conserved residues affecting key regions of the kinase domain. These data represent a paradigm for the unbiased analysis of signal transducing genes in cancer and provide useful targets for therapeutic intervention.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bardelli, Alberto Turin, IT 20 77
Kinzler, Kenneth W Baltimore, US 282 4776
Parsons, D Williams Bellaire, US 18 78
Velculescu, Victor Dayton, US 54 617
Vogelstein, Bert Baltimore, US 324 6303

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