Methods and compositions for enhancing targeted transgene integration

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United States of America Patent

PATENT NO 10889834
APP PUB NO 20160168593A1
SERIAL NO

14967885

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Abstract

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Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease or a hemophilia by administering one or more topoisomerases inhibitors, one or more stabilizers of R loop formation or inhibitors of R-loop repair and/or one or more up-regulators of the TC-NER pathway to the target cell.

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Patent Owner(s)

  • SANGAMO THERAPEUTICS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cost, Gregory J Richmond, US 27 1549
Wechsler, Thomas Richmond, US 15 405

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