ISOLATION AND PURIFICATION OF SHIKIMIC ACID
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United States of America Patent
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Jun 23, 2016
app pub date -
Dec 18, 2015
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Dec 19, 2014
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Abstract
A method for isolating and purifying shikimic acid from a fermentation broth is provided. The method includes performing a liquid-liquid extraction on the fermentation broth with an alcohol solution to generate an extract, crystallizing solids from the extract, dissolving the solids in a second alcohol solution to generate a solution having shikimic acid, and filtering the solution having shikimic acid through a filter that does not contain ion exchange resins. Methods for dehydrating the shikimic acid to yield p-hydroxybenzoic acid are also provided.
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