Diagnosis and treatment of chronic obstructive pulmonary disease (COPD) based on elevated levels of extracellular H3 protein

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United States of America Patent

PATENT NO 9933435
SERIAL NO

15044649

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Abstract

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Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.

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Patent Owner(s)

  • TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barrero, Carlos A Philadelphia, US 9 15
Kelsen, Steven G Rydal, US 4 13
Merali, Salim Bryn Mawr, US 14 15
Moncada, Camilo Philadelphia, US 5 4
Perez, Leal Oscar Mauricio Barranquilla, CO 3 1

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