Modulation of γδ T cells

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United States of America Patent

PATENT NO 10759863
APP PUB NO 20160194403A1
SERIAL NO

14916986

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Abstract

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The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδT cells. Specifically, the present invention provides methods of modulating γδT cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7.

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Patent Owner(s)

  • SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Sedy, John R La Jolla, US 4 16
Ware, Carl F La Jolla, US 26 196

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