Cancer Treatment Comprising Therapeutics That Bind to Phosphatidylserine
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United States of America Patent
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Issued Date -
Jul 14, 2016
app pub date -
Mar 24, 2016
filing date -
Mar 24, 2016
priority date (Note) -
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Abstract
Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.
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