METHODS OF QUALITY CONTROL USING SINGLE-NUCLEOTIDE POLYMORPHISMS IN PRE-IMPLANTATION GENETIC SCREENING

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United States of America Patent

APP PUB NO 20160210404A1
SERIAL NO

14995354

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Abstract

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The present invention provides methods for validating results of a pre-implantation genetic screen. Methods of the invention increase the efficacy of the common PGS assay FAST-SeqS by taking advantage of single-nucleotide polymorphisms (SNPs) generated from the assay to confirm copy number calls, detect errors, identify samples, and recognize and identify sources of contamination. Methods of the invention increase the reliability of a PGS result, thereby making embryo selection more precise and improving outcomes of in vitro fertilization.

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Patent Owner(s)

Patent OwnerAddress
LABORATORY CORPORATION OF AMERICA HOLDINGS531 SOURTH SPRING STREET BURLINGTON NC 27215

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gore, Athurva Cambridge, US 14 183
Porreca, Gregory Cambridge, US 35 456
Umbarger, Mark Brookline, US 39 632

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