Adsorption of immunopotentiators to insoluble metal salts

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United States of America Patent

PATENT NO 10098949
APP PUB NO 20160213776A1
SERIAL NO

15093652

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Abstract

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Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS S.A

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cortez, Alex San Diego, US 14 170
Hoffman, Timothy Z San Diego, US 17 138
Li, Yongkai San Diego, US 21 158
Pan, Jianfeng San Diego, US 20 40
Singh, Manmohan Cary, US 101 2140
Skibinksi, David A G Singapore, SG 1 0
Wu, Tom Yao-Hsiang San Diego, US 34 179
Yue, Kathy Minneapolis, US 5 90
Zhang, Xiaoyue San Diego, US 16 171
Zou, Yefen San Diego, US 11 58

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