Cross-metathesized polysaccharide derivatives and processes for preparing them

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United States of America Patent

PATENT NO 10738134
APP PUB NO 20160215068A1
SERIAL NO

15025451

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Abstract

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Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an exemplary embodiment, a method for the synthesis of cellulose ω-carboxyesters via olefin cross-metathesis is described. Conditions of the reactions were relatively mild and the olefin-substituted polysaccharides and the appropriate monomeric olefin partners appear to follow Grubbs rules as summarized herein. The compounds and methods may be useful for structure-property studies, particularly those aimed at developing polymers for drug delivery, such as for controlled-release drug delivery systems, controlled-release coatings, increasing bioavailability of drugs, and maintaining drug supersaturation in the GI tract.

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Patent Owner(s)

Patent OwnerAddress
VIRGINIA TECH INTELLECTUAL PROPERTIES INC901 PRICES FORK ROAD VIRGINIA TECH HOLTZMAN ALUMNI CENTER 3RD FLOOR BLACKSBURG VA 24061

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edgar, Kevin J Blacksburg, US 24 233
Matson, John Blacksburg, US 4 281
Meng, Xiangtao Blacksburg, US 10 7

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