MACROMOLECULES OF DENDRIMER-PLATINUM CONJUGATES
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United States of America Patent
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Aug 4, 2016
app pub date -
Sep 10, 2014
filing date -
Sep 10, 2014
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Abstract
A macromolecule comprising a dendrimer having surface amino groups to which at least one platinum-containing moiety is attached is provided. The macromolecule may have a plurality of platinum-containing moieties attached to the surface amino groups. Alternatively, the macromolecule may comprise a dendrimer having surface amino groups to which at least two different moieties are attached, a first moiety being a platinum-containing moiety and the second moiety being a pharmacokinetic modifying agent or targeting agent. Pharmaceutical compositions comprising the macromolecules and uses of the macromolecules for treating or suppressing the growth of a cancer is also described.
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