Enzyme/Protein Packaged Bacterial Vesicles for Therapeutic Delivery

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United States of America Patent

APP PUB NO 20160222372A1
SERIAL NO

15010966

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Abstract

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A method of producing a protein includes providing a bacterial cell expressing both (a) a protein of interest fused to one of the SpyTag/SpyCatcher pair and (b) an outer membrane protein fused to the other of the SpyTag/SpyCatcher pair; causing the bacterial cell to express both of the protein of interest fusion and the outer membrane protein fusion in outer membrane vesicles; and purifying the outer membrane vesicles.

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Patent Owner(s)

Patent OwnerAddress
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY875 NORTH RANDOLPH STREET SUITE 1425 NAVAL RESEARCH LABORATORY ARLINGTON VA 22203

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alves, Nathan Fairfax, US 2 3
Anderson, George P Bowie, US 29 314
Medintz, Igor L Springfield, US 38 170
Turner, Kendrick Washington, US 5 11
Walper, Scott Springfield, US 8 3

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