TISSUE ENGINEERING USING PROGENITOR CELLS TO CATALYZE TISSUE FORMATION BY PRIMARY CELLS

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United States of America Patent

APP PUB NO 20160228610A1
SERIAL NO

15137439

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. The progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. In particular, adipose-derived stem cells and chondrocytes, co-encapsulated in a mixed culture in a polyethylene glycol-based hydrogel comprising an extracellular matrix molecule such as chondroitin sulfate methacrylate, hyaluronic acid methacrylate, or heparan sulfate methacrylate, effectively produce cartilage that can be used for treatment of traumatic injuries or diseases involving cartilage degeneration.

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Patent Owner(s)

Patent OwnerAddress
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYBUILDING 170 THIRD FLOOR MAIN QUAD P O BOX 20386 STANFORD CA 94305-2038

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lai, Janice Mountain View, US 5 171
Maloney, William Menlo Park, US 8 77
Smith, R Lane Palo Alto, US 16 108
Yang, Fan Stanford, US 695 3994

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