DRUG SENSITIVITY BIOMARKERS AND METHODS OF IDENTIFYING AND USING DRUG SENSITIVITY BIOMARKERS
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United States of America Patent
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Aug 11, 2016
app pub date -
Oct 17, 2014
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Oct 17, 2013
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Disclosed are methods based on correlation of drug effects with genetic alterations in specific sub-regions of proteins. The presence of such genetic alterations in subjects with a relevant disease allows more directed treatment of the disease, ideally limited to subjects having a genetic alteration in the drug effect-correlated sub-region of a protein. Disclosed are methods of identifying subjects, treating subjects, identifying specific drug effect-correlated protein sub-regions, and identifying drugs correlated with specific protein sub-regions, all based on the discovered correlation of drug effects with genetic alterations in specific sub-regions of proteins.
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