Renal Progenitor Cells

Number of patents in Portfolio can not be more than 2000

United States of America Patent

APP PUB NO 20160237409A1
SERIAL NO

14898213

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method is provided for simultaneously producing both nephron progenitor cells and ureteric epithelial progenitor cells including the step of contacting intermediate mesoderm cells with: fibroblast growth factor (9) and/or fibroblast growth factor (20) and optionally, one or more selected from the group consisting of. bone morphogenic protein 7; heparin: a Wnt agonist; retinoic acid; and an RA antagonist. The concentrations of Writ agonist, retinoic acid and/or RA antagonist may be manipulated to favour the relative production of nephron progenitor cells and ureteric epithelial progenitor cells. The intermediate mesoderm cells are ultimately derived from human pluripotent stem cells via a posterior primitive streak stage. The nephron progenitor cells and ureteric epithelial progenitor cells may have end uses such as for kidney repair and regeneration, bioprinting of kidneys and screening compounds for nephrotoxicity.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF QUEENSLANDQUEENSLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
LITTLE, Melissa Queensland, AU 3 1
TAKASATO, Minoru Toowon Queensland, AU 2 1

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