VACCINE COMPRISING PROTEIN NMB0964 FROM NEISSERIA MENINGITIDIS

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United States of America Patent

SERIAL NO

14990142

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Abstract

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The present invention relates to immunogenic compositions comprising neisserial blebs with upregulated levels of the NMB0964 antigens such that bactericidal antibodies are generated against said antigen. It has been found for the first time that this antigen's expression is zinc regulated and therefore methods are provided to upregulated expression through removal of the zinc repression mechanism of the cell or promoter, or through removal of zinc from the culture medium.

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Patent Owner(s)

Patent OwnerAddress
GLAXOSMITHKLINE BIOLOGICALS S A1330 RIXENSART
UTRECHT UNIVERSITYPADUALAAN 8 UTRECHT NL-3584

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bos, Martine Petronella Utrecht, NL 5 56
Poolman, Jan Rixensart, BE 118 1131
Stork, Michiel Utrecht, NL 6 11
Tommassen, Johannes Petrus Maria Utrecht, NL 16 77
Weynants, Vincent Rixensart, BE 30 131

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