4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections

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United States of America Patent

PATENT NO 10882851
APP PUB NO 20160257673A1
SERIAL NO

14990322

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention provides quinazoline derivatives represented by the structural formula: (I); wherein: R2 is hydrogen, NR′R″, C1-7 alkyl, arylC1-7 alkyl or C3-10 cycloalkyl; R4 is amino, C1-7 alkyl, C2-7 alkenyl, C3-10 cycloalkyl, C3-10 cycloalkenyl, aryl, heterocyclic, arylalkyl, heterocyclic-substituted C1-7 alkyl or C3-10 cycloalkyl-C1-7 alkyl; R5 is hydrogen or C1-7 alkyl, or R5 and R4 together with the nitrogen atom to which they are attached form a heterocyclic ring; Y is a single bond, C1-7 alkylene, C2-7 alkenylene or C2-7 alkynylene; R6 is halogen, heteroaryl or aryl; R′ and R″ are each independently hydrogen, C1-7 alkyl-carbonyl or C1-7 alkyl; provided that R4 is not phenyl substituted with morpholino when R2 is H and R5 is H, and provided that when NR4R5 is piperazinyl, said NR4R5 is either non-substituted or substituted with methyl or acetyl; a pharmaceutically acceptable addition salt, a stereoisomer, a mono- or a di-N-oxide, a solvate or a pro-drug thereof, for the treatment of viral infections.

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Patent Owner(s)

  • GILEAD SCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chong, Lee Shun Newark, US 8 190
De, Jonghe Steven Cesar Alfons Brussels, BE 16 419
Gao, Ling-Jie Heverlee, BE 14 274
Herdewijn, Piet André Maurits Maria Rotselaar/Wezemaal, BE 8 189
Watkins, William John Saratoga, US 13 374

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