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Abstract

The present disclosure provides an antimicrobial composition including a polycationic amphiphile compound, and the method of making and the method of using such a compound or composition. The compound having the formula (I) or (II) R₁, R₂, R₃, R₄, R₅, R₆, R₁₀, or R₁₁ is H or a C_1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH₂, —NHR′, —NR′₂, —N—C(O)R′, —N—C(O)CR′═CR′, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF₃, —OCF₃, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl. R₇, R₈ or R₉ is a C_1-12 alkyl unsubstituted or optionally substituted with a functional group such as —OH, —OR′, —NH₂, —NHR′, —NR′₂, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF₃, and —OCF₃. R′ is H or a C_1-4 alkyl. X or Y is a halogen, m and n are integers in the range from 1 to 25.

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First Claim