Muscle Derived Cells for the Treatment of Gastro-Esophageal Pathologies and Methods of Making and Using the Same

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United States of America Patent

SERIAL NO

15067351

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Abstract

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The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration of symptoms for gastro-esophageal pathologies like gastro-esophageal reflux.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATIONPITTSBURGH PENNSYLVANIA 15260

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chancellor, Michael B Pittsburgh, US 61 753
Jankowski, Ronald Pittsburgh, US 31 57
Pasricha, Jay Ellicott City, US 9 19
Pruchnic, Ryan Pittsburgh, US 23 30

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