Methods and compositions for diagnosis and prognosis of renal injury and renal failure
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United States of America Patent
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May 28, 2019
Grant Date -
Oct 20, 2016
app pub date -
Dec 3, 2014
filing date -
Dec 3, 2013
priority date (Note) -
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Abstract
It is an object of the present invention to provide methods and compositions for protection of subjects from acute kidney injury by treating the subject with compounds that modulate the cell cycle. Modulating the cell cycle can comprise inducing G0/G1 cell cycle arrest, and/or inducing cell cycle progression. As demonstrated below, even a single administration of a compound which induces G0/G1 cell cycle arrest can protect subjects from AKI, and may be used prophylactically in advance of, or as a treatment following, various treatments or conditions that are known to be injurious to the kidney, followed optionally by release of the arrest. Once AKI is established, cell cycle progression can be induced to increase replacement of lost and damaged cells.
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