METHOD OF INDUCING AN IMMUNE RESPONSE

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United States of America Patent

APP PUB NO 20160312228A1
SERIAL NO

15005940

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method is provided for inducing or enhancing an immune response in a mammal to a target polypeptide expressed in a plurality of cells of the mammal, which method comprises administering to the mammal an inhibitory nucleic acid which targets a region of a ribonucleic acid (RNA) which encodes said polypeptide. Also provided is a pharmaceutical composition comprising an inhibitory nucleic acid which targets a region of an RNA which encodes a target polypeptide expressed in a plurality of cells of a mammal, such that translation of an aberrant form of the target polypeptide occurs in said cells, said truncated form of the target polypeptide comprising one or more T cell epitopes; together with a pharmaceutically acceptable carrier or diluent.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF QUEENSLANDST LUCIA QUEENSLAND 4067

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gu, Wenyi Brisbane, AU 3 2
Leggat, Graham Brisbane, AU 1 0
McMillan, Nigel Brisbane, AU 3 2

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