Modulation of synaptic maintenance

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United States of America Patent

PATENT NO 10240156
APP PUB NO 20160326534A1
SERIAL NO

15222603

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Abstract

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C1q is shown to be expressed in neurons, where it acts as a signal for synapse elimination. Methods are provided for protecting or treating an individual suffering from adverse effects of synapse loss. These findings have broad implications for a variety of clinical conditions, including treating and preventing neurodegenerative diseases such as Alzheimer's disease.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barres, Ben A Palo Alto, US 27 162
Stephan, Alexander H Stanford, US 2 30
Stevens, Beth A Milton, US 11 129

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