Fusion of heterooligomeric mycobacterial antigens

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United States of America Patent

PATENT NO 10765731
APP PUB NO 20160331823A1
SERIAL NO

15110514

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates generally to novel immunogenic combinations comprising or encoding at least two heterooligomeric mycobacterial antigens and preferably a fusion polypeptide comprising said two heterooligomeric mycobacterial antigens, where the mycobacterial antigens are selected from the group of Esx, PE and PPE antigens of a Mycobacterium species, particularly a Mycobacterium of the tuberculosis complex such as Mycobacterium tuberculosis (Mtb). The present invention also relates to vectors, host cells and compositions comprising or encoding said immunogenic combination as well as to methods for expressing and producing it. The present invention also relates to methods of using said immunogenic combination, fusion polypeptide, vector, host cell, composition particularly for inducing or stimulating an immune response with the goal of providing a protective response against a Mycobacterium infection or any disease caused by or associated with a Mycobacterium infection.

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Patent Owner(s)

  • TRANSGENE SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Marchand, Jean-Baptiste Obernai, FR 16 124
Penin, François Decines, FR 2 0
Silvestre, Nathalie Ergersheim, FR 27 82

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